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Talk to your rheumatologist and your other healthcare providers before you begin to take anything new or if you have any changes to your medications during your treatment with ORENCIA.

Tell your rheumatologist if you are taking other biologic medicines, such as:.

Doing so may increase your chances of getting a serious infection. You should avoid taking ORENCIA with other biologics that may affect your immune system. ORENCIA and other medicines may affect each other, which could cause serious side effects. What should I avoid while I am on ORENCIA? Talk to your healthcare provider about the best way to feed your baby if you use ORENCIA. It is not known if ORENCIA passes into breast milk.

Breastfeeding or planning to breastfeed.

Women are encouraged to call the registry themselves or ask their healthcare provider to contact the registry for them by calling The purpose of this registry is to check the health of the pregnant mother and her child.

There is a registry for pregnant women exposed to ORENCIA.

If ORENCIA is taken during pregnancy, talk to your healthcare provider before your baby receives any vaccines. It is not known if ORENCIA can harm an unborn baby.

Let your rheumatologist know if you are a woman who is:.

Prescription medications or over-the-counter medications.

Other medications for RA, pJIA, or PsA.

If you are receiving ORENCIA, and for 3 months after you stop receiving ORENCIA, you should not take live vaccines.

You recently received or are scheduled to receive vaccinations.

Tell your rheumatologist about all of your medical treatments, including if:.

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Some people treated with ORENCIA have developed skin cancer. You have a family or personal history of skin cancer, or see any growths or changes in the appearance of your skin during or after treatment with ORENCIA.ORENCIA IV contains maltose, which can alter the blood sugar readings with certain types of blood glucose monitors. Your healthcare provider may tell you to use a different way to monitor your blood sugar levels on the day that you receive ORENCIA IV infusion. You have Chronic Obstructive Pulmonary Disease (COPD), a type of lung disease.

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For a list of ingredients, see What are the ingredients in ORENCIA? in the Patient Information section of the Full Prescribing Information.

You have allergies to the ingredients of ORENCIA.

Call your rheumatologist if you notice any symptoms of TB, including: a cough that does not go away, weight loss, fever, or night sweats. Before starting ORENCIA, your rheumatologist may check you for TB or do a skin test. Tell your rheumatologist if you have ever had TB or a positive skin test for TB, or have recently been in close contact with someone who has ever had TB.

Tuberculosis (TB), a type of lung infection.

Before starting ORENCIA, your rheumatologist may examine you for hepatitis. Tell your rheumatologist if you have or have ever had viral hepatitis.

Viral hepatitis, a viral infection that affects the liver.

Any infection that will not go away or a history of infections that keep coming back.

Small infections (such as an open cut or sore) to whole body infections (such as the flu).

You have any kind of infection, as you may have a higher chance of getting serious side effects from an infection while taking ORENCIA.

Talk to your rheumatologist about all of your medical conditions, including if:.

What should I discuss with my rheumatologist before starting ORENCIA?

Talk to your rheumatologist about the best way for you or your child to receive ORENCIA.

The ability of pediatric patients to self-inject with the autoinjector has not been tested.

PJIA patients may self-inject with ORENCIA or the patient’s caregiver may administer ORENCIA if both the healthcare practitioner and the parent/legal guardian determines it is appropriate.

ORENCIA SC prefilled syringe is available for patients 2 years and older.It is available as a prefilled syringe or a ClickJect™ Autoinjector. ORENCIA subcutaneous (SC) injection is a shot that is given just under your skin.

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